NEK1 is involved in tumor growth through altered immune signaling

Turbine’s Simulated Cell™ platform models cancer cell signaling to predict cell viability and to identify novel drug targets. By simulating perturbations of the DNA-damage response (DDR) pathway, we identified NEK1 as a cancer dependency in certain molecular contexts. NEK1 is part of the NIMA-related kinase family, involved in DDR, cell cycle, and mitosis, making it an interesting candidate for antitumor intervention.